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Beilstein J. Org. Chem. 2011, 7, 1688–1696, doi:10.3762/bjoc.7.199
Graphical Abstract
Scheme 1: Synthesis of 6,8-diiodocoumarin derivatives 1–7.
Scheme 2: Proposed fragmentation pathways for the EI ions of the substituted 6,8-diiodocoumarins 3 and 7.
Scheme 3: Synthesis of 6,8-diiodocoumarin-3-N-carboxamide derivatives 8–11.
Scheme 4: Synthesis of ethyl cyanoacetate and pyridine derivatives 12 and 13.
Scheme 5: Synthesis of 1,3-oxazocine derivatives 14a,b.
Figure 1: Graphical representation of the antibacterial activity of tested compounds compared to ampicillin.
Figure 2: Graphical representation of antifungal activity of tested compounds, compared to calforan.